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Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII.

(Accepted June 29, 1998.) Interaction of Human Papillomavirus DNA with Factor XIIIa-positive Dermal Dendrocytes in Vulvar Lesions Naiura Vieira Pereira 1,2 , Carla Pagliari 1,2* , Elaine R. Fernandes 1 , Fernanda Guedes 1 , Mírian N. Sotto 2 and Maria Irma Seixas Duarte 1 PDF | Factor XIIIa-positive dendrocytes present at the periphery and inside epithelial neoplasms are an heterogeneous group of cells. They are subsets | Find, read and cite all the research you Factor XIIIa is a pan-histiocytic marker, similar to CD68. 1999-10-18 · FXIIIa is a 80 kDa subunit of the blood coagulation factor XIII, also found in cells belonging to the megakaryocyte/platelet and the monocyte/macrophage cell lineages (Adany, 1996). The aim of the present study was to evaluate the contribution of factor XIIIa (FXIIIa)-positive dermal dendritic cells to formation of keloids and hypertrophic scars.

In contrast, 18 (75%) of 24 DFSPs stained for factor XIIIa (mean factor-XIIIa score, 1.3 +/- 0.2), but in most of these cases the factor-XIIIa-positive cells were felt to be entrapped nonneoplastic dermal dendrocytes. Factor Xiiia staining Four of 10 (40%) compound nevi, 9 of 20 (45%) radial growth-phase melanomas, and 12 of 20 (60%) vertical growth-phase melanomas showed an increase in factor Xllla staining of DDCs (Ta-ble 1). The majority of cases, with the exception of 3 vertical growth-phase melanomas, had only slight (1-I-) increased staining (Fig. 1 By dual-labeling immunofluorescence and confocal microscopy, GPIbα-positive cells within the dermal interstitium are demonstrated to represent factor XIIIa-positive dermal dendrocytes. In organ cultures of neonatal human foreskin, mast cell degranulation induced by either substance P or compound 48/80 resulted in transiently increased GPIbα expression by dermal dendrocytes.

Plasmacytoid dendritic cells, Factor XIIIa-positive dermal dendrocytes, by doublestaining technique with antiCD68 and antiiNOS antibodies in forty-three skin biopsies and anti-factor XIIIa and antiiNOS antibodies in thirty-four biopsies, comparing findings between different tissue response patterns.

Mirian Nacagami Sotto. mnsotto@ajato.com.br .

Anti- Factor XIIIa has been found to be useful in differentiating between dermatofibroma (90% positive) and desmoplastic malignant melanoma (negative). Factor XIIIa positivity is also seen in capillary hemagioblastoma, hemangioendothelioma, hemangiopericytoma, xanthogranuloma, xanthoma, hepatocellular carcinoma, glomus tumor , and meningioma.

Factor XIIIa-positive dendrocytes are almost absent in the reticular dermis and markedly reduced in number and size in the adventitial dermis. By contrast, the densities of vimentin-positive cells and CD34-positive cells were unremarkable. The biologic significance of this finding is unknown. Factor XIIIa Positive Control Slides , Product No. 251S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections). Other Notes For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com Newcomer Supply Factor XIIIa (fibrin stabilizing factor) Control Slides are for the positive immunohistochemical staining of Factor XIIIa, a blood coagulation enzyme that crosslinks fibrin. Factor XIIIa is used as a marker for fibro-histiocytic proliferations, dermal dendritic cells and to differentiate dermatofibroma from dermatofibrosarcoma. ical aid to the diagnosis of the most frequent type of EDS. Factor XIIIa-positive dendrocytes are almost absent in the reticular dermis and markedly reduced in number and size in the adventitial dermis.

Positive inotropic agents increase myocardial contractility, and are used to Activation of factor XIII to factor XIIIa, which augments production of fibrin clots from Figur XIII. MEDELKONCENTRATIONER AV METALLER/HALVMETALLER UNDER DE TRE Vidare redovisas i Tabell XIII koncentrationen (i % av TS) av.
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CD68 may highlight histiocytic cells (Patterson: Weedon's Skin Pathology, 5th Edition, 2020) FXIIIa positive cells in human skin represent a specific population of bone-marrow dermal dendritic cells, distinct from Langerhans cells, that share some features common to mononuc-lear phagocytes (monocyte/macrophages).

They are subsets of mesenchymal cells, cancer-associated macrophages Factor XIIIa-positive cells were most numerous in the dermis and connective tissues. Numerous large, stellate cells in placental villi, decidua, and chorionic membranes also expressed factor XIIIa at 7-9 weeks gestational age, before the onset of fetal hematopoiesis. Anti- Factor XIIIa has been found to be useful in differentiating between dermatofibroma (90% positive) and desmoplastic malignant melanoma (negative).
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Factor XIIIa (reportedly positive in neurofibroma but negative in schwannoma), and CD56 (reportedly nega-tive in neurofibroma and positive in schwannoma, although I have seen focal CD56 in a plexiform neurofi-broma). We have also evaluated neurofilament in a number of these types of cases, and I have observed neu-

Factor XIIIa-positive cells were most numerous in the dermis and connective tissues. Numerous large, stellate cells in placental villi, decidua, and chorionic membranes also expressed factor XIIIa at 7-9 weeks gestational age DOI: 10.1097/00000372-199810000-00022 Corpus ID: 11184222. CD34 and factor XIIIa-positive microvascular dendritic cells and the family of fibrohistiocytic mesenchymal tumors. @article{Silverman1998CD34AF, title={CD34 and factor XIIIa-positive microvascular dendritic cells and the family of fibrohistiocytic mesenchymal tumors.}, author={J. Silverman and A. Tamsen}, … Anti- Factor XIIIa has been found to be useful in differentiating between dermatofibroma (90% positive) and desmoplastic malignant melanoma (negative).